Open AccessAN IMMUNOHISTOCHEMICAL STUDY OF NEOVASCULATURE IN HUMAN BRAIN TUMORS
Author(s) -
Sawada Tatsuo,
Nakamura Mari,
Sakurai Isamu
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb02343.x
Subject(s) - pathology , immunohistochemistry , fibronectin , cytoplasm , reactivity (psychology) , antigen , chemistry , medicine , biology , extracellular matrix , immunology , microbiology and biotechnology , alternative medicine
In order to elucidate the characteristics of newly‐formed small blood vessels in brain tumors, 51 cases of various types of brain tumor were studied immuno‐histochemically. Endothelial cells in all tumor types reacted positively with anti‐Factor VIH‐related antigen (F‐VIII Ag) and UEA‐1. Reactivity to UEA‐1 was limited to endothelial cytoplasm. Proliferating immature endothelial cells showed weak reactivity to anti‐F‐VIII Ag. In some cases of benign tumors diffuse reactivity to anti‐F‐VIII Ag was noted throughout thickened medial areas of the vascular walls, in which reactivity to anti‐fibrous collagen and anti‐flbronectin was noted. UEA‐1 was thought to be a more specific endothelial marker than F‐VIII Ag, especially for proliferating and Immature endothelial cells. It is strongly suspected that fibrous collagens are related to the formation of a thickened vascular wall in newly‐formed small tumor vessels.