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ENCEPHALOMYELONEURITIS WITH MEDIASTINAL GERM CELL TUMOR A Paraneoplastic Condition ?
Author(s) -
Kawaguchi Kenji,
Kishida Shuji,
Okeda Riki,
Funata Nobuaki,
Koike Morio
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb02307.x
Subject(s) - pathology , paraneoplastic cerebellar degeneration , malignancy , histopathology , germ cell tumors , encephalitis , medicine , mediastinum , teratoma , mature teratoma , neoplasm , autoantibody , anatomy , immunology , virus , chemotherapy , antibody
An unusual case of encephalomyeloneuritis associated with germ cell tumor with mature and immature teratoma arising in the mediastinum is presented. There was an unusually long interval from the onset of neurologic symptoms to the development of malignancy. The histopathology, characterized by limbic encephalitis, brain stem encephalitis, cortical cerebellar degeneration and myeloneuritis, was similar to that of paraneoplastic encephalomyeloneuritis previously described in the literature. Virological and immunological studies failed to demonstrate any causative agents or autoantibodies reacting with brain tissue. The causal relationship between the malignant neoplasm and encephalomyeloneuritis thus seems to be very complex.

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