Open AccessCARDIAC RHABDOMYOMA: A Case Report with Reference to Atrial Natriuretic Peptide
Author(s) -
Takatoh Hidekichi,
Iwamoto Hisashi,
Ikezu Mitsuru,
Katoh Norio,
Kaneko Hiroshi,
Ishikawa Hiroshi,
Kamoi Kyuji
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb01076.x
Subject(s) - rhabdomyoma , atrial natriuretic peptide , autopsy , medicine , atrium (architecture) , myocyte , hamartoma , pathology , cardiology , anatomy , tuberous sclerosis , atrial fibrillation
An autopsy case of cardiac rhabdomyoma in a male infant is reported. Many nodules of rhabdomyoma were present in all four cardiac chambers and were microscopically composed of ovoid, glycogen‐laden cells and typical “spider cells”. Atrial natriuretic peptide (ANP) was immunohistochemically demonstrated in both normal myocytes and rhabdomyoma cells of both atria, but not in normal myocytes and rhabdomyoma cells of both ventricles. Ultrastructurally, atrial specific granules were present in atrial rhabdomyoma cells and normal atrial cardiocytes, and these showed ANP immunoreactivity with protein A‐gold technique. It could be said that the localization and intracel‐Mar distribution of ANP in this cardiac rhabdomyoma were closely similar to those of normal human heart. With regard to the presence of ANP, cardiac rhabdomyoma cells arising in atria seemed to differ from those in ventricles, although many tumor nodules occurred in both atria and ventricles. Furthermore, it seemed that cardiac rhabdomyomas could also be divided into two parts: 1) an atrial part with ANP, and 2) a ventricular part without ANP. Therefore, this study confirms the hypothesis that cardiac rhabdomyoma is a hamartoma rather than a true neoplasm. ACTA PATHOL JPN 38 : 95–104, 1988.