Open AccessSUPPRESSIVE EFFECT OF CYCLOSPORIN A ON THE INDUCTION OF CHRONIC SERUM SICKNESS NEPHRITIS IN THE RAT
Author(s) -
Shigematsu Hidekazu,
Koyama Akio
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb01068.x
Subject(s) - serum sickness , nephritis , medicine , pathology , cyclosporins , immunology , transplantation , antibody
The suppressive effect of cyclosporin A (CyA) on the development of antibody‐induced glomerulonephritis was analyzed in rats with serum sickness nephritis. The induction of serum sickness was established by preimmunization and subsequent continuous administration of the same antigen starting 1 month later. When CyA was given in the preimmunization stage, neither induction of glomerulonephritis nor specific antibody response was observed. In contrast, when CyA was administered in the stage of continuous sensitization, mild glomerulonephritis as well as specific antibody response developed. This phenomenon implles that the significant inhibition of the occurrence of immune complex nephritis results from the suppression by CyA of its primary response to the sensitizing antigen. ACTA PATHOL JPN 38: 11–19, 1988.