Open AccessULTRASTRUCTURAL MORPHOGENESIS OF MITOCHONDRIA IN ALCOHOLIC LIVER
Author(s) -
Chang Eun Sook
Publication year - 1987
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1987.tb03057.x
Subject(s) - ultrastructure , pathology , mitochondrion , electron microscope , pleomorphism (cytology) , alcoholic liver disease , morphogenesis , abnormality , biology , medicine , microbiology and biotechnology , immunohistochemistry , biochemistry , cirrhosis , physics , psychiatry , gene , optics
Electron microscopic studies of 53 diagnostic liver biopsies from 23 patients were done. Ultrastructural study revealed most striking alteration to be in the mitochondria such as pleomorphism in shape and size, especially giant mitochondria with disorganization, crystalline inclusions and calcium‐like electron dense bodies. These ultrastructural changes might have been induced by specific bichemical abnormality in alcohol bearing condition. Diagnostic use of electron microscopy will be useful in detecting alcoholic injury in alcoholic patient who fails to demonstrate any discernible laboratory and light microscopic abnormalities.