Open AccessEFFECT OF HYPERLIPIDEMIA ON GLOMERULAR SCLEROSIS IN UNILATERAL NEPHRECTOMIZED RATS
Author(s) -
Miyata Junichi,
Takebayashi Shigeo
Publication year - 1987
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1987.tb02265.x
Subject(s) - hyperlipidemia , medicine , endocrinology , glomerulosclerosis , proteinuria , kidney , diabetes mellitus
The development of focal segmental glomerular sclerosis (FSGS) and its relation to hypertriglycemia were studied in unilateral nephrectomized rats. Group A (n=6), fed standard rat chow supplemented with 20% beef tallow and 0.6% cholic acid for 25 weeks, showed evidence of hypertriglycemia (109.4 ±4.3 mg/dl). Group B (n=7) was given the same rat chow as group A, but they did not have high serum levels of TG (66.4 ±2.3 mg/dl). Group C (n = 6) were the controls and their serum TG levels were 53.0 ±3.8 mg/dl. The incidence of FSGS and body weight was significantly higher in group A than in groups B (<0.01) and C (<0.05). In all three groups, rats with over a 4% FSGS revealed significantly high serum TG levels, proteinuria, and body weight, as compared with rats with less than 1% of FSGS. The serum cholesterol levels did not correlate with the incidence of FSGS. We tentatively conclude that hypertriglycemia induced by a diet rich in saturated fatty acid may play an importent role in the production and progression of FSGS.