Open AccessINDUCTION OF MELANOGENESIS IN SCHWANN CELL AND PERINEURAL EPITHELIUM BY 9, 10‐DIMETHYL‐l, 2‐BENZANTHRACENE (DMBA) AND 12‐o‐TETRADECANOYLPHORBOL‐13‐ACETATE (TPA) IN BDF 1 MICE
Author(s) -
Kanno Jun,
Matsubara Osamu,
Kasuga Tsutomu
Publication year - 1987
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1987.tb00462.x
Subject(s) - dmba , 12 o tetradecanoylphorbol 13 acetate , benzanthracene , epithelium , chemistry , pathology , medicine , carcinogen , carcinogenesis , phorbol ester , biochemistry , protein kinase c , gene , enzyme
Six‐week‐old female BDF, mice were treated with a single topical application of DMBA followed by repeated application of TPA on the clipped dorsal skin. Several weeks after DMBA application, the intradermal melanocytes of perifollicular melanocytic network began to proliferate to form melanocytic tumors in all treated mice skin. Besides these changes, single membrane‐bound melansomes and premelanosomes were found in the cytoplasm of perineural epithelia and Schwann cells with mesaxons of the nerve bundles involved, and the melanogenic activity of the Schwann cell and the perineural epithelium of the dermal peripheral nerve bundle was discussed in terms of a common feature of neuro‐ectodermal cells.