Open AccessSYSTEMIC AMYLOID ARTHROPATHY ASSOCIATED WITH MULTIPLE MYELOMA
Author(s) -
Kurashima Chieri,
Hirokawa Katsuiku,
Kato Kotaro,
Shimada Hiroyuki,
Esaki Yukiyoshi,
Miwa Tetsuyoshi,
Mori Mayumi
Publication year - 1987
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1987.tb00419.x
Subject(s) - pathology , medicine , autopsy , multiple myeloma , bone marrow , arthropathy , amyloidosis , amyloid (mycology) , immunoglobulin light chain , systemic disease , immunopathology , antibody , immunology , osteoarthritis , alternative medicine
This is the first report of an autopsy case of systemic amyloid arthropathy associated with multiple myeloma in Japan. The patient was a 72‐year‐old male who had been suffering from multiple myeloma (IgA‐lambda) with extensive arthropathy of the systemic joints. Autopsy examination revealed severe deposit of amyloid in the articular cavities of the systemic joints showing a feature of amyloidoma. Furthermore, numerous amyloid deposits were found in the wall of small blood vessels in the major organs. In the bone marrow, there were many atypical plasma cells and foamy cells both showing positive reaction for IgA and lambda light chain. No such atypical cells were observed in the other organs except for the bone marrow.