Open AccessMULTICENTRIC HEPATOCELLULAR CARCINOMA FOLLOWING PHOSPHATE DIETHYLSTILBESTROL THERAPY FOR PROSTATIC CANCER
Author(s) -
Endo Hisako,
Murakami Toshikazu,
Nishimoto Ikuo,
Serine Imao,
Yokoyama Masao
Publication year - 1987
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1987.tb00413.x
Subject(s) - diethylstilbestrol , hepatocellular carcinoma , medicine , peliosis hepatis , liver cancer , pathology , cancer , carcinoma , autopsy , gynecomastia , estrogen
This paper reports an autopsy case of a 78‐year‐old male with multiple nodules in the liver developed after longtermed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer. Large part of these nodules were suspected to be well differentiated hepatocellular carcinoma with high level of serum alpha‐fetoprotein (AFP) up to 3,400 ng/ml, but a part of them was evaluated to be a borderline between hepatocellular carcinoma and adenoma with mild cellular atypism. The liver other than the nodules showed liver fibrosis associated with liver cell dysplasia and peliosis hepatis‐like change. This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.