Open AccessVIRUS‐LIKE PARTICLES IN CULTURED C 3 H/St MOUSE CELLS TREATED WITH A CARCINOGENIC POLYCYCLIC HYDROCARBON
Author(s) -
Iseki Eizo,
Matsumoto Yoh,
Takahashi Hitoshi,
Ikuta Fusahiro
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb03115.x
Subject(s) - carcinogen , cytoplasm , virus , organelle , alveolar cells , in vivo , microbiology and biotechnology , pathology , chemistry , cell , lung , strain (injury) , biology , virology , biochemistry , anatomy , medicine , genetics
Virus‐like particles with cylindrical form were found in cultured alveolar macrophages and lung fibroblasts of C 3 H/St mice, after treating these cells with a carcinogenic polycyclic hydrocarbon, 1, 2, 5, 6, ‐Dibenzanthracene (DBA). Their morphology looked identical to those observed in vivo in the reactive cells which engulfed DBA crystals implanted into the brain and muscle of the same mouse strain. These particles were not found in either the untreated cells of C 3 H/St mice or the treated cells of BALB/c mice. In the alveolar macrophages, these particles appeared first at 3 days after DBA treatment and reached the maximum number around the 30th day. They still kept their morphology in the degenerating cells which had lost the cytoplasmic organelles. These findings suggest the possibility that DBA induced the expression of the viral genome endogeneous to C 3 H/St cell.