Open AccessSCANNING ELECTRON MICROSCOPIC STUDY OF PRECANCEROUS and CANCEROUS PANCREATIC LESIONS INDUCED BY N‐NITROSOBIS (2‐OXOPROPYL) AMINE IN SYRIAN GOLDEN HAMSTERS
Author(s) -
Naito Zenya,
Takahashi Miohihito,
Furukawa Fumio,
Toyoda Kazuhiro,
Hasegawa Ryohei,
Hayashi Yuzo
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02856.x
Subject(s) - histogenesis , pathology , golden hamster , pancreas , electron microscope , mesocricetus , chemistry , scanning electron microscope , pancreatic duct , hamster , anatomy , biology , medicine , endocrinology , immunohistochemistry , materials science , physics , optics , composite material
Sequential alteration of Syrian golden hamster pancreatic ducts and ductules was investigated by scanning electron microscope during and subsequent to 10 weekly subcutaneous injections of N‐nitrosobis (2‐oxopropyl) amine (BOP). By examining surface morphology of ductal cells and resin casts of the secretory branches arising from the common duct, a series of lesions ranging from slight derangement of the luminal dimensions and loss of cilia to marked projections of “finger‐like” processes accompanied by pleomorphism at the cellular and microvilli levels and increase in numbers of goblet cells could be established. A ductal histogenesis is proposed on the basis of the present scanning electron microscopic and earlier light microscopic findings. ACTA PATHOL. JPN. 36: 1359–1366, 1986.