Open AccessEXPERIMENTAL STUDY ON SECONDARY AMYLOIDOSIS ASSOCIATED WITH CHRONIC ARTHRITIS
Author(s) -
Aoki Shigehisa,
Ikuta Koji,
ogaki Tsunemasa,
Nagamatsu Kiyokazu
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02854.x
Subject(s) - amyloidosis , pathology , medicine , arthritis , dermatology
Various organs from rabbits immunized with heat‐killed E. eoli 0: 14 to induce chronic polyarthritis resembling rheumatoid arthritis (RA) were examined for amyloid deposition since amyloidosis is a frequent feature of long‐standing RA. Amyloids were confirmed mainly by polarizing as well as nonpolarizing light microscopy after Congo red staining and partly by electron microscopy and immunoperoxidase technique. Amyloid deposits after an additional 2 months from the first appearance of arthritis were most frequently found in the spleen and kidneys suggesting secondary amyloidosis. Amyloidosis was observed in 36% of 75 arthritic rabbits. The incidence of amyloidosis was significantly higher in the arthritic rabbits than in the non‐arthritic rabbits (plt0.05). This suggests that prolonged sensitization with heat‐killed E. coli 0:14 containing endotoxic substance participates in the formation of both arthritis and amyloidosis. ACTA PATHOL. JPN. 36: 1335 ‐1346, 1986.