Open AccessCYTOPLASMIC INCLUSIONS AND VIRUS‐LIKE PARTICLES IN BLAST CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
Author(s) -
Ishihara Tokuhiro,
Matsumoto Noboru,
Yamashita Yoshimi,
Takahashi Mutsuo,
Uchino Fumiya,
Inoue Masamitsu,
Yano Shigeru,
Tanaka Hiroyuki,
Shinohara Kenji,
Kaneko Toshio
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02844.x
Subject(s) - vacuole , virus , inclusion bodies , cytoplasm , cytoplasmic inclusion , electron microscope , virology , ultrastructure , lysosome , pathology , lymphoblastic leukemia , chemistry , biology , biophysics , leukemia , microbiology and biotechnology , medicine , immunology , physics , biochemistry , escherichia coli , gene , optics , enzyme
Cytoplasmic inclusions and virus‐like particles are described in blast cells of peripheral blood from a 16‐year‐old female with acute lymphoblastic leukemia. Three kinds of inclusions were identified on electron microscopy. The first type of inclusion was single membrane‐bounded vacuoles, some of which contained virus‐like particles, the second was lysosome‐like structures, and the third appeared to be of mitochondrial origin. Virus‐like particles were round in shape and had a diameter of 26 to 58 nm. They consisted of an electrondense outer membrane and an electron‐lucent core. At the present time the exact nature and significance of these virus‐like particles still remain unclear.