Open AccessEXPERIMENTAL MESANGIOPROLIFERATIVE GLOMERULONEPHRITIS IN RATS INDUCED BY INTRAVENOUS ADMINISTRATION OF ANTI‐THYMOCYTE SERUM
Author(s) -
Ishizaki Masamichi,
Masuda Yukinari,
Fukuda Yuh,
Sugisaki Yuhichi,
Yamanaka Nobuaki,
Masugi Yozo
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02839.x
Subject(s) - nephritis , glomerulonephritis , medicine , antibody , mesangial proliferative glomerulonephritis , pathology , endocrinology , immunology , kidney
Focal glomerulonephritis was induced in rats, by a single intravenous injection of anti‐Thy‐1.1 antibody (ATS). One hour after the administration, the glomeruli of affected rats developed necrotic changes of the mesangial cells while after two hours, mesangiolytic changes appeared. From six days onwards, focal segmental mesangial proliferation which persisted until 30 days, occurred. This is thought to be the first report of experimental nephritis induced by pure anti‐mesangial antibody.