Open AccessDETECTION OF IMMUNOGLOBULINS AND OTHER SERUM PROTEINS IN THE DERMAL AND GLOMERULAR CAPILLARY WALLS FROM PATIENTS WITH DIABETES MELLITUS
Author(s) -
Inoue Wataru,
Tomino Yasuhiko,
Miura Masahiko,
Yagame Mitsunori,
Nomoto Yasuo,
Sakai Hideto
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02838.x
Subject(s) - diabetes mellitus , diabetic nephropathy , medicine , microangiopathy , nephropathy , renal biopsy , antibody , pathology , proteinuria , antiserum , biopsy , endocrinology , immunology , kidney
Deposition of immunoglobulins or acute phase reactant (APR) proteins in the dermal and glomerular capillary walls from patients with diabetes mellitus was examined to determine whether development of microangiopathy in such patients was related to exudation and/or entrapment of these proteins. Skin and renal biopsy specimens were obtained from patients with diabetic nephropathy and diabetes mellitus without nephropathy. These biopsy samples were stained with FITC‐labeled anti‐human IgG, IgA, IgM, C3, APR proteins, and β‐Hpoprotein antisera. Linear depositions of IgA, IgG and/or APR proteins were observed in the dermal and/or glomerular capillary walls from some patients with diabetic nephropathy or diabetes mellitus without nephropathy. It is indicated that deposition of such immunoglobulins in the dermal and glomerular capillary walls might be due to exudation and/or entrapment of these substances in patients with diabetes mellitus.