Open AccessMUCORMYCOSIS IN DIABETIC KETOACIDOSIS: Role of Unbound Iron Binding Capacity of Transferrin
Author(s) -
Abe Fumihiko,
Shibuya Hiroyuki,
Tateyama Miki,
Ommura Yuuta,
Azumi Norio,
Kimura Kazuyuki
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02822.x
Subject(s) - diabetic ketoacidosis , transferrin , mucormycosis , medicine , pathology , endocrinology , physiology , diabetes mellitus
Increased susceptibility to Rhizopus oryzae in diabetes was investigated using mice in which diabetic ketoacidosis was experimentally induced. All of the diabetic mice which had developed ketoacidosis died within four days after inoculation of R. oryzae and their serum UIBCs (Unbound iron binding capacity) were significantly lower than those of the normal control mice. This study suggested that the decreased serum UIBC produced by diabetic ketoacidosis enhances the growth of R. oryzae in vivo . ACTA PATHOL. JPN. 36: 1507‐1512, 1986.