Open AccessEXPRESSION OF IgD ON B CELL MALIGNANCY|An Immunopathological Study of 50 Cases
Author(s) -
Mori Shigeo,
Hagiwara Shizuo,
Kodo Hideki,
Mohri Noboru
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02815.x
Subject(s) - immunoglobulin d , antigen , blastoid , biology , b cell , immunoglobulin light chain , pathology , microbiology and biotechnology , antibody , immunology , medicine , lymphoma , mantle cell lymphoma
Expression of IgD was studied immunopathologically on 50 cases of B cell lymphomas (B MLs), together with various B cell markers including IgM, ϰ and Λ chains, B1, B2, (OK)B2, (OB)B7, (OK)T10, NUB1, Leu 1, Leu 14, and PCA. IgD was demonstrated on 19 cases heavily and on 8 weakly. It associated well with expression of two antigens, B2 (C3d receptor molecule) and Leu1 (pan‐T antigen), besides IgM, while, B2 was closely related in expression on B MLs to (OK)B2, (OK)B7, and NUB1. Λ chain was dominant on IgD heavily‐stained cases. Histopathologically, IgD positive MLs were distributed in various types. All of diffuse intermediate type were shown to be IgD positive (4/4, 3 heavily). As cases of this type were shown to express most of other B cell antigens present on non‐tumorous primary follicle B cells or mantle zone B cells, this type of MLs is speculated to be a neoplastic counterpart of such non‐tumorous B cells. Eight out of 18 cases of diffuse large cell type were IgD heavily positive, suggesting some unusual mechanisms in IgD expression on these neoplastic large cells, as non‐tumorous B cells lose most of their surface IgD soon after blastoid transformation. Other types of MLs were discussed with special emphasis on expression of IgD. ACTA PATHOL. JPN. 36: 1429‐1440, 1986.