Open AccessNEUROTHEKEOMA: Report of a Case with Immunohistochemical and Ultrastructural Studies
Author(s) -
Henmi Akihiro,
Sato Hideaki,
Wataya Tomiyuki,
Inaniwa Yoshimi,
Mori Yoshiomi
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02256.x
Subject(s) - pathology , immunohistochemistry , ultrastructure , anatomy , medicine , biology
A case of neurothekeoma in a 52‐year‐old woman is reported. The tumor developed on the medial aspect of the right nostril as a well‐demarcated, dome‐shaped, erythematous nodule of rubbery consistency. Microscopically, it consisted of numerous nests and cords of spindle‐shaped cells in the dermis. Some of the tumor cell nests appeared epithelial‐like, while the other areas showed a myxomatous appearence with various amount of mucinous matrix in the intercellular space. Neurothekeoma is a benign cutaneous tumor, and is considered to be of schwann cell origin. In the present case, the tumor cells did not stain positively for S‐100 protein, despite the light microscopic suggestion of peripheral nerve origin. Ultrastructurally, most tumor cells contained a large number of myelinoid figures. This ultrastructural finding appears to be a useful diagnostic characteristics of neurothekeomas.