Open AccessCALCITONIN‐PRODUCING INSULINOMA: An Immunohistochemical and Electron Microscopic Study
Author(s) -
Ooi Akishi,
Nakanishi Isao,
Kameya Toru,
Funaki Yoshinori,
Kobayashi Katsuyoshi
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02254.x
Subject(s) - pathology , calcitonin , immunohistochemistry , medicine , insulinoma , pancreas
A pancreatic endocrine tumor measuring 1.5×1.0×1.0 cm in a 67‐year‐old man with recurrent hypoglycemic attacks was examined by immunohistochemistry and electron microscopy. The tumor cells were relatively uniform, and almost all of them were immunoreactive to Insulin. A few calcitoninpositive cells could be identified scattering in tumor cell strands, and the content of calcitonin in the tumor was 85 ng/g wet tissue. Coexistence of insulin and calcitonin in tumor cells was demonstrated by using adjacent semithin sections of the Epon‐embedded material. Electron microscopically, the tumor consisted of a single type of cells with secretory granules identical to B‐cell granules in the normal counterpart.