Open AccessHETEROTRANSPLANTATION OF OVARIAN SEROUS ADENOCARCINOMA WITH FUNCTIONING STROMA TO NUDE MICE: Disappearance of Functioning Stroma in Transplanted Tumor
Author(s) -
Kataoka Akio
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02249.x
Subject(s) - stromal cell , estrogen , stroma , serous fluid , ovary , pathology , adenocarcinoma , medicine , biology , immunohistochemistry , cancer
Serous adenocarcinoma of the ovary with estrogen and alpha‐fetoprotein (AFP) production was serially heterotransplanted into nude mice. The original tumor presented marked luteinization of stromal cells with elevated urine levels of estrogen before the operation. Estrogen levels reduced to the normal level shortly after the operation. Histologic features of the original tumor were basically retaind in the transplanted tumor, but no luteinization of stromal cells was observed and serum estrogen levels in nude mice were elevated. Immunohlstochemically, AFP was found to be positive in some tumor cells of transplanted tumor, but serum AFP levels were not elevated.