Open AccessBIZARRE LEIOMYOBLASTOMA OF THE CERVIX UTERI
Author(s) -
Ito Hisao,
Sasaki Naomi,
Miyagawa Kazuyasu,
Tahara Eiichi
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb02237.x
Subject(s) - histogenesis , cervix , pathology , myosin , uterus , myofilament , biology , anatomy , medicine , immunohistochemistry , endocrinology , cancer , microbiology and biotechnology
A case of bizarre leiomyoblastoma (BL) of the cervix uteri which developed in a 44‐year‐old premenopausal woman was reported. The tumor was found as a cervical polyp by routine pelvic examination. Histologically, it was composed of epithelioid and bizarre, often multlnucleated, giant tumor cells without elevated mitotic counts and necrosis. Electronmicroscopically, abundant myofilaments in epithelioid tumor cells were observed. Immunoreactive desmln, GPK‐MM (creatinine kinase mm‐isozyme), and myosin could be demonstarted in most of the epithelioid tumor cells. These immunohisto‐chemical findings seemed to reflect on the differentiation of the tumor cells to smooth muscle and provide a reliable evidence for the smooth muscle origin. The histogenesis and relationship between the histopathological findings and clinical behaviour of uterine BL were also discussed.