Open AccessPSEUDOMEMBRANOUS COLITIS IN A PATIENT OF PARAQUAT INTOXICATION
Author(s) -
Imamura Takahisa,
Tsuruta Junji,
Kambara Takeshi,
Maki Shôjirô
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb01484.x
Subject(s) - submucosa , pseudomembranous colitis , pathology , autopsy , medicine , paraquat , fibrin , fibrosis , colitis , lung , edema , blood capillary , pathogenesis , gastroenterology , antibiotics , biology , surgery , clostridium difficile , immunology , biochemistry , circulatory system , microbiology and biotechnology
A 49 year‐old man drank paraquat 7–8 fold of human fatal dose, and died of severe respiratory failure in 24 days in spite of intensive therapy. The autopsy revealed diffuse pulmonary fibrosis caused by prolonged intoxication of paraquat An intersting finding was many raised plaques from 1 mm to 10 mm in diameter, observed in whole colon. Histologically, these plaques were composed of necrotic mucosa (“pseudomembrane”), disrupted crypts and edematous submucosa with fibrin eduction, intervening in normal colon tissue with sharp margins, and diagnosed as non‐antibiotic‐induced pseudomembranous colitis. Since the edematous submucosa of the raised plaque had a stratified fibrin eduction around a dilated capillary, it was speculated that the vessel injury by paraquat might play a role in the pathogenesis of pseudomembranous colitis.