Open AccessMALLORY BODY‐LIKE STRUCTURES IN THE LUNG
Author(s) -
Shimizu Shinichi,
Kobayashi Hiroshi,
Watanabe Hisashi,
Ohnishi Yoshihisa
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb01464.x
Subject(s) - keratin , pathology , lung , cytoplasm , pathological , intermediate filament , ultrastructure , biology , medicine , microbiology and biotechnology , cell , cytoskeleton , genetics
Mallory body‐like structures (MBLs), which resemble Mallory body (MB) in the liver, were observed in lungs of 4 cases showing interstitial pneumonitis. MBLs were found in the cytoplasm of especially swollen alveolar epithelial cells. MBLs and MBs had almost similar characteristics morphologically and tinctorially under the light microscopy. MBLs were composed of intermediate type fine fibrils which were positive for anti‐keratin antibody. These findings suggested that MBLs were a kind of pathological keratinization of alveolar epithelial cells. Although the origin of MBL containing cells could not be clarified, they were closely related to type 2 alveolar epithelial cells.