Open AccessNEUROFILAMENTS OF KULTSCHITSKY CELLS IN HUMAN LUNG
Author(s) -
Torikata Chikao,
Mukai Makio,
Kawakita Hirobumi,
Kageyama Keizo
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb01463.x
Subject(s) - neurofilament , intermediate filament , antiserum , pathology , lung , microtubule , microbiology and biotechnology , biology , chemistry , cytoskeleton , antibody , immunohistochemistry , immunology , cell , medicine , biochemistry
The immunohlstochemical localization of three triplet proteins of neurofilaments in normal Kultschitsky cells and tumourlets of the human lung has been studied using avidin‐biotin‐poroxidase complex (ABC) method. Kultschitsky cells and tumourlets have been stained with antisera against 68 K, 150 K and 200 K dalton components of the nourofilaments, respectively. Ultra‐structural observations of human Kultschitsky cells have revealed the presence of bundles of intermediate filaments as well as microtubules and neurosecretory‐type granules. In the tumourlets, similarly sized filaments were found, but were relatively scarce. Since intermediate filaments are thought to be specific to differentiated cells and neurofilament proteins are restricted to the neuronal tissues, we conclude that Kultschitsky cells of the lung are of neuronal nature.