Open AccessINTESTINAL METAPLASIA‐DYSPLASIA‐CARCINOMA SEQUENCE OF THE GALLBLADDER
Author(s) -
Yamagiwa Hiroshi,
Tomiyama Hiroki
Publication year - 1986
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1986.tb00209.x
Subject(s) - dysplasia , intestinal metaplasia , carcinoma , gallbladder , metaplasia , pathology , medicine , gastroenterology
One thousand cases of respected gallbladders were histologically investigated by serial step sections. Intestinal metaplasia was found at rates of 4.0% and 30.6% in the cases without and with stone, respectively. It was found at rates of 69.8% and 61.1% in the cases of dysplasia and carcinoma, respectively. The goblet cells were found at rates of 34.5% and 26.3% in the lesions of carcinoma and dysplasia, respectively. On the other hand, the dysplasia and adenoma Intermingled in the tumor tissue at the rates of 22.2% and 8.3% in 36 cases of carcinoma, respectively. Although normal epithelial cells of the gallbladder contain mainly sulfomucln, the goblet cells have sialomucin. The ratio of sialomucin‐containing cells increased in the tissue of dysplasia and carcinoma. As to their location, intestinal metaplasia, dysplasia, and carcinoma showed a similar distribution in the gallbladder. Accordingly, it should be considered that the sequence of intestinal metaplasia‐dysplasia‐carcinoma is significant Pseudo‐pyloric glandular metaplasia was found at rates of 45.5% in the cases of cholecystitis without stone, 77.2% in those with stone, 100% in those with dysplasia, and 72.3% in those with carcinoma. However, it should be considered that pseudo‐pylorlc glandular metaplasia has less relationship for the bases of carcinogenesls as compared with intestinal metaplasia.