Open AccessPROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
Author(s) -
Hayashi Tohru,
Sumiyoshi Akinobu,
Tanaka Masayuki,
Araki Shukurou,
Minamishima Yoichi
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb02216.x
Subject(s) - pathology , progressive multifocal leukoencephalopathy , autopsy , medicine , lesion , spinal cord , cerebrum , immunohistochemistry , cytoplasmic inclusion , slow virus , central nervous system , virus , biology , virology , cytoplasm , biochemistry , psychiatry , endocrinology
Clinical, light‐ and electron microscopic, and immunohistochemical findings of a 44‐year‐old woman with progressive multifocal leukoencephalopathy were presented. Autopsy revealed a wide distribution of the demyelinating lesion in the cerebrum, cerebellum, brain stem and spinal cord, and intranuclear inclusion bodies and papova‐like virions in transmission electron microscopy in the nuclei of oligodendrocytes. SV40 antigen was immunohistochemically detected in these inclusion bodies. The widespread extension of the lesions seemed to correlate with the duration of the patient's illness. The prolongation of the clinical course in this case may be dependent upon the lack of serious underlying diseases except for a small nodule of thyroid carcinoma, SV40 infection rather than JC virus infection and/or improved care of that kind of patient.