Open AccessDIFFUSE PANBRONCHIOLITIS WITH MULTIPLE TUMORLETS
Author(s) -
WATANABE Hisashi,
KOBAYASHI Hiroshi,
HONMA Keiichi,
OHNISHI Yoshihisa,
IWAFUCHI Mitsuya
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb01012.x
Subject(s) - diffuse panbronchiolitis , neuroendocrine cell , pathology , calcitonin , medicine , chromogranin a , immunohistochemistry , biology , erythromycin , antibiotics , microbiology and biotechnology
An autopsy case of diffuse panbronchiolitis with incidentally observed multiple tumorlets was reported. Quantitative study revealed the distribution and number of single Kultschitzky cell and its cluster. These cells were more frequently observed in the present case than in 20 control cases, and moreover, they tended to occur more frequently in the pulmonary segment in which tumorlets were found and there was an apparent transition of them into tumorlets. Immunohistochemically, gastrin‐releasing peptide, calcitonin, and serotonin were demonstrable in the cells which consisted of both tumorlets and Kultschitzky cell clusters. It is suggested that the Kultschitzky cell is a precursor cell of the tumorlet and that tumorlet is benign, being hyperplastic in nature.