Open AccessINTESTINAL METAPLASIA INDUCED BY X‐IRRADIATION IN DIFFERENT STRAINS OF RATS
Author(s) -
Watanabe Hiromitsu,
Naito Masashi,
Kawashima Kengo,
Ito Akihiro
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb00626.x
Subject(s) - intestinal metaplasia , metaplasia , alkaline phosphatase , endocrinology , medicine , strain (injury) , inbred strain , biology , irradiation , stomach , biochemistry , enzyme , gene , physics , nuclear physics
Attempts were made to examine strain differences in the susceptibility of rats to intestinal metaplasia induced by X‐irradiation. The gastric regions of 4 inbred male rats (SHR, F344, WKY, and LEW strains) in 5‐week‐old and 2 random bred male rats (SD, and WIS strains) were irradiated with a total dose of 20 Gy X‐ray given in two equal fractions separated by three days. Upon sacrifice at 6 months after the last irradiation, the number of intestinal metaplastic crypts with positive reaction to alkaline phosphatase (ALP) appeared highest in the SHR and lowest in the WIS rats. Morphologically, the number of crypts with intestinal metaplasia in whole glandular stomachs of SHR, WIS, F344, and SD rats were higher than those in WKY and LEW rats. In the pyloric gland, it was highest in WIS rats, while in the fundic gland it was highest in SHR rats. The results show that the appearance and location of intestinal metaplasia by X‐irradiation are greatly influenced by the strain of the rat. ACTA PATHOL. JPN. 35: 841–847, 1985.