Open AccessSOLITARY GASTRIC POLYPS IN THE FUNDIC GLAND AREA A Histochemical Study
Author(s) -
Hara Masafumi,
Tsutsumi Yutaka,
Watanabe Keiichi,
Suzuki Sohtaro,
Tani Norio,
Miwa Takeshi
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb00625.x
Subject(s) - pathology , gastric polyp , gastric glands , medicine , anatomy , stomach , gastric mucosa
Six solitary gastric polyps in the acid‐secreting fundic mucosa were histo‐chemically investigated using the mucin histochemistry, immunoperoxidase method, and silver methods for endocrine cells. Histologically, the polyps were grouped into three types : they largely consisted of either hyperplastic foveolar cells (group 1), normal‐appearing fundic gland cells with mild cystic changes (group 2) or hyperplastic fundic gland cells with cystic dilatation (group 3). The presence of parietal cells and mucous neck cells was confirmed in all polyps by the immunoperoxidase method using parietal cell autoantibody and the paradoxical Concanavalin A staining, respectively. Regarding the endocrine component, somatostatin‐containing cells, Grimelius‐positive argyrophil cells, and Fontana‐Masson‐positive enterochromaffin cells were scattered in the fundic gland area of the polyps as well as in the surrounding normal‐appearing fundic mucosa. Gastrin‐containing cells were absent. In one of the group 2 polyps and both group 3 polyps, a varying number of glicentin‐containing cells were found among the fundic gland components : In one polyp in group 3, glucagon immunoreactivity was detected in the glicentin‐containing cells. These findings suggest that some of the polyps express characteristics of the fetal fundic mucosa, since glicentin and glucagon immunoreactivities in normal human stomach have been detected exclusively in the fetal fundus. ACTA PATHOL. JPN. 35: 831–840, 1985.