Open AccessEOSINOPHILIC GASTROENTERITIS
Author(s) -
Oyaizu Naoki,
Uemura Yoshiko,
Izumi Haruaki,
Morii Sotokichi,
Nishi Masaharu,
Hioki Koshiro
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb00617.x
Subject(s) - eosinophilic gastroenteritis , immunoglobulin e , pathology , infiltration (hvac) , eosinophilic , eosinophil , medicine , immunohistochemistry , stomach , lesion , mast cell , eosinophilia , allergy , immunology , antibody , asthma , physics , thermodynamics
A surgical case of a middle‐aged Japanese with eosinophilic gastroentertis is described. This 50‐year‐old man presented protein‐losing gastroenter‐opathy, iron‐deficiency anemia, and marked elevation of serum IgE, in whom the lesion formed a diffuse thickening of almost the entire portion of the stomach. Microscopically, there was an intense infiltration of eosinophils throughout the whole thickness of the gastric wall, interspersed with plasma cells and lymphocytes. On the affected area, an increased number of IgE‐positive plasma cells and surface IgE‐positive mast cells, some of which are degranulated, were identified. These Immunohistochemical findings provide a strong evidence for IgE mast cell‐mediated allergy concerning this disorder. ACTA PATHOL. JPN. 35 : 759–766, 1985.