Open AccessGLOMERULAR DEPOSITION OF IgA IN EXPERIMENTAL HEPATIC CIRRHOSIS
Author(s) -
Iida Hiroyuki,
Izumino Kiyoshi,
Matsumoto Michio,
Takata Masanobu,
Mizumura Yasuji,
Sugimoto Tsuneaki
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb00598.x
Subject(s) - cirrhosis , proteinuria , glomerulonephritis , immunoglobulin a , glomerular mesangium , nephropathy , pathology , carbon tetrachloride , ccl4 , medicine , chemistry , endocrinology , antibody , kidney , immunology , immunoglobulin g , organic chemistry , diabetes mellitus
Wistar rats rendered cirrhotic with carbon tetrachloride excreted significant proteinuria and hematuria. Serum levels of IgA and IgG were significantly elevated in cirrhotic animals. They showed mild mesangial proliferation and immunofiuorescent studies revealed deposits of IgA and IgG predominantly in mesangial areas and along capillary walls. These findings were very similar to those seen in patients with hepatic cirrhosis or IgA nephropathy. The deposits of IgA were also found in hepatic tissue from cirrhotic animals. The intensity and distribution of glomerular IgA deposits were not diminished after treatment with acid buffer. These results suggest that glomerular IgA are IgA polymers and decreased hepatic clearance of hepatic IgA polymers may be responsible for the glomerular deposition of IgA. ACTA PATHOL. JPN. 35: 561–567, 1985.