Open AccessGASTRIC CARCINOIDS OF ECL CELLS
Author(s) -
Grigioni W.F.,
Caletti G.C.,
Gabrielli M.,
Marrano D.,
Villanacci V.,
Mancini A.
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb00581.x
Subject(s) - gastrin , pathology , hyperplasia , stomach , enteroendocrine cell , antrum , enterochromaffin like cell , carcinoid tumors , medicine , endocrine system , g cell , gastric mucosa , hormone , secretion
Clinical, histological, histochemical and ultrastructural characteristics of eight cases of carcinoid tumors of the non‐antral portion of the stomach are presented. Four cases with multiple polypoid lesions are accompanied by an increased level of gastrin. A normal level of gastrin was present in the other four cases with isolated tumor and a normal component of endocrine cells in the uninvolved mucosa. In the first group with multiple lesions, the histological and histochemical analysis of the endocrine cells revealed a wide range of appearances: a) “simple hyperplasia”, b) “nodular hyperplasia”, and c) carcinoid tumor. These aspects suggested a different pathogenesis for the carcinoid tumors of the non‐antral portion of the stomach with possible therapeutical implications. ACTA PATHOL. JPN. 35: 361–375, 1985.