Open AccessPATHOGENESIS OF PORTAL SCLEROSIS IN THE LIVER WITH IDIOPATHIC PORTAL HYPERTENSION
Author(s) -
Fukuda Kazunori,
Arakawa Masahiro,
Kage Masayoshi,
Matsumoto Shinichi,
Nakashima Toshiro,
Okuda Kunio
Publication year - 1985
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1985.tb00575.x
Subject(s) - pathogenesis , portal hypertension , medicine , nodular regenerative hyperplasia , portal venous pressure , pathology , portal vein , autopsy , portal vein thrombosis , thrombosis , intimal hyperplasia , cirrhosis , smooth muscle , radiology , gastroenterology
The pathomorphological changes of intrahepatic portal veins were studied in 19 autopsy cases of idiopathic portal hypertension (IPH), and the pathogenesis of portal sclerosis was discussed by the observations on the human and experimental materials. The degree and morphological appearance of intimal lesions vary from vessel to vessel. Fibrocellular proliferation of subendothelial tissue and incorporation of organized mural thrombi were suggested as the cause of intimal thickening in the portal veins. Animal experiment showed that injury of portal vein wall was followed by intimal hyperplasia and/ or incorporation of mural thrombi, and resulted in portal sclerosis similar to that of IPH liver. The cause of portal phlebosclerosis in IPH can not be explained by passive congestion alone. There might be a certain possibility of direct injurious effect in the vessel wall in the pathogenesis of portal lesions of IPH. The following pathogensis of portal sclerosis in IPH is postulated: phlebosclerotic changes of the portal veins are initiated by injury to the vessel wall due to unknown cause (s) and accelerated by secondary thrombosis and/ or mechanical injury due to increased portal pressure.TA PATHOL. JPN. 35: 299–314, 1985.