Open AccessInhibitor of plasminogen activator in human arterial wall: I. Histochemical Study
Author(s) -
Okamura Takashi,
Nanno Shigeru,
Sueishi Katsuo,
Tanaka Kenzo
Publication year - 1984
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1984.tb07602.x
Subject(s) - urokinase , fibrinolysis , plasmin , plasminogen activator , arterial wall , fibrin , pathology , arteriosclerosis , chemistry , plasminogen activator inhibitor 1 , medicine , endocrinology , immunology , biochemistry , enzyme
An inhibitor of urokinase, human urinary plasminogen activator, was found in the media of human arteries using a histochemical method (fibrin slide sandwich technique). Arteriosclerotic lesions, especially atherosclerosis, apparently contained the urokinase inhibitor. The inhibitor did not alter plasmin activity. This inhibitor of urokinase may be involved in regulation of fibrinolysis in arterial wall and thus a significant role in atherogenesis. Acta pathol. jpn. 34: 743∼747, 1984.