Open AccessANGIOGENESIS OF CULTURED ENDOTHELIAL CELLS OF BOVINE CORONARY ARTERY
Author(s) -
Nohara Masatoshi,
Tanimura Akira,
Nagayama Kazuhiko,
Nakashima Teruyuki
Publication year - 1984
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1984.tb02185.x
Subject(s) - vacuole , vacuolization , pathology , angiogenesis , endothelial stem cell , endothelium , biology , chemistry , microbiology and biotechnology , anatomy , cytoplasm , medicine , in vitro , biochemistry , endocrinology , cancer research
Endothelial cells of bovine coronary artery were isolated and cultivated and bovine clots were placed in the cultured endothelial cells (42 generations), followed by observation on the 14th day. Cultured endothelial cells not only covered the surface of each clot but also migrated in it to form oval or irregularly shaped intracytoplasmic vacuoles or sometimes intercellular vacuoles surrounded by 2 or 3 cells. Some of these vacuoles contained membranous materials. This vacuolization was considered to represent angiogenetic activity peculiar to endothelial cells.