Open AccessCLINICOPATHOLOGICAL STUDY ON THE RELATIONSHIP BETWEEN SERUM‐CEA AND TISSUE‐CEA OF RESECTED LUNG CANCER CASES
Author(s) -
Okamura Akiharu,
Ohkawa Jiro,
Fujisawa Hiroshi,
Sashikata Terumasa
Publication year - 1984
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1984.tb00549.x
Subject(s) - adenocarcinoma , pathology , mucin , medicine , small cell carcinoma , lung cancer , carcinoma , metastasis , cancer
The clinicopathological correlation between serum‐CEA (s‐CEA) and immunohistological tissue‐CEA (t‐CEA) was studied on 63 cases of operated lung cancers. T‐CEA was examined by peroxidase anti‐peroxidase (PAP) method. T‐CEAs were detected in 36/39 cases (92.3%) of adenocarcinoma, 16/16 cases (100%) of epidermoid carcinoma, 2/5 cases (40%) of large cell carcinoma, and 1/ 3 case (33.3%) of small cell carcinoma. T‐CEAs in adenocarcinoma and large cell carcinoma with much exhibited moderate to strong reactivity with diffuse distribution, and also s‐CEA of these cases indicated high levels. On the contrary, in epidermoid carcinoma t‐CEAs showed a weak reactivity with focal distribution, and s‐CEAs also demonstrated low levels. In adenocarcinoma it was suggested that the more cancers were differentiated, the more t‐CEA and s‐CEA were increased, and about two third of cases showed a balance between t‐CEA and much content in cancer tissue. S‐CEAs were not correlated with the size of the primary lesion or the extent of lymph node metastasis, but with the histological types, i.e. high levels of s‐CEA in adenocarcinoma and large cell carcinoma with mucin. ACTA PATHOL. JPN. 34: 1209–1219, 1984.