Open AccessEXPERIMENTAL PHOSPHOLIPIDOSIS INDUCED BY 4,4′‐DIETHYL‐AMINOETHOXYHEXESTROL
Author(s) -
Tashiro Yukio,
Watanabe Yonosuke,
Enomoto Yasuhiro
Publication year - 1983
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1983.tb02140.x
Subject(s) - phospholipidosis , cytoplasm , golgi apparatus , inclusion bodies , ultrastructure , cytoplasmic inclusion , lysosome , organelle , pathology , drug , biology , chemistry , microbiology and biotechnology , phospholipid , biochemistry , medicine , pharmacology , enzyme , membrane , endoplasmic reticulum , escherichia coli , gene
The effect of a generalized phospholipidosis inducing drug, diethylamino‐ethoxyhexestrol (DH, a coronary vasodilator), was studied using rats. The initial alterations are characterized by the appearance of abnormal cytoplasmic inclusion bodies. At the early stage of DH administraion, they appeared near the Golgi apparatus. Histochemical and ultrastructural evidence showed that the inclusion bodies consisted of polar lipid, mainly of phospholipids. From cytochemical and biochemical observation, the lysosome was regarded as the primary site of the drug‐induced morphological changes. The drug‐induced abnormal cytoplasmic inclusion bodies were of three basic morphological types, i.e., multilamellated, crystalloid and finger‐print‐like bodies. Additionally, many intermediate forms were found showing structural features of those basic types. These drug‐induced cytoplasmic changes, namely storage of phospholipids, were considered to be reversible both morphologically and biochemically after the cessation of DH administration.