Open AccessATROPHIC GASTRITIS INDUCED BY INJECTION OF XENOGENEIC STOMACH ANTIGEN IN MICE
Author(s) -
Watanabe Hiromitsu,
Naito Masashi,
Ito Akihiro
Publication year - 1983
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1983.tb02117.x
Subject(s) - atrophy , stomach , gastritis , atrophic gastritis , pathology , antigen , medicine , immunology
Wistar/Furth rat stomach antigen emulsified with an equal volume of Freund's complete adjuvant was subcutaneously injected into several strains of mice. Atrophy of the glandular stomach was produced in A/HeJ mice, but not in CF 1 , C57BL/6J or ICR/JGL mice. Atrophy of the glandular stomach was found to become most severe in 4‐month‐old animals. In 6‐month‐old mice and 12‐month‐old mice, atrophy was not observed. The increase in atrophy corresponds with the dose of antigen.