Open AccessULTRASTRUCTURAL CHARACTERISTICS OF DUODENAL SOMATOSTATINOMAS
Author(s) -
KANEKO Hiroshi,
SUMIDA TosMko,
TOSHIMA Muneatsu,
KOBAYASHI Hiroshi,
KITAZAWA Mikio
Publication year - 1983
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1983.tb01423.x
Subject(s) - vesicle , ultrastructure , granule (geology) , pathology , chemistry , gastric chief cell , biology , membrane , anatomy , stomach , biochemistry , medicine , gastric mucosa , paleontology
Ultrastructural findings of granules and vesicles appearing in tumor cells of somatostatinoma are reported. Except for D granules, one granule and four kinds of vesicles were discerned. Some tumor cells had granules of the exocrine type which were similar to those of the chief cells of the stomach. Very small clear vesicles (YO and KO) had accumulated mainly in the apical region of the somatostatinoma cells. Both vesicles were round, unit–membrane bounded and clear in the center, each measuring about 90 and 30 nm in diameter. The cored vesicles normally seen in the sympathetic system were revealed. Doughnut vesicles characterized by double contour membranes were detected together with the cored vesicles. A mixutre of exocrine cells of the chief cell–type in the paraneuroma has not been previously reported. And we have as yet very little information as to the doughnut vesicle. ACTA PATHOL. JPN. 33: 359–366, 1983.