Open AccessJUVENILE GRANULOSA CELL TUMOR ASSOCIATED WITH RAPID DISTANT METASTASES
Author(s) -
Takeuchi Hisakiyo,
Hamada Hiroshi,
Sodemoto Yukio,
Ushigome Shinichiro
Publication year - 1983
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1983.tb00360.x
Subject(s) - pathology , cytoplasm , granulosa cell , eosinophilic , juvenile , cell , endoplasmic reticulum , metastasis , cancer , biology , medicine , ovary , endocrinology , microbiology and biotechnology , genetics
We have encountered a case of juvenile granulosa cell tumor, first described by SCULLY as a specific form of granulosa cell tumor, in a 23‐year‐old, nul‐liparous female associated with some unusual clinicopathological features. The tumor showed a diffuse or macrofollicular pattern with eosinophilic or clear, often vacuolated cytoplasm containing abundant lipid. Ultrastructures revealed features very similar to those of previously reported juvenile granulosa cell tumor. Intracytoplasmic filaments were observed, but smooth surfaced endoplasmic reticulums were not evident. The patient succumbed unexpectedly rapidly due to recurrence and distant metastasis, in spite of anti‐cancer therapy. It is also interesting that suprisingly high levels of estrogens as well as testosterone in both urine and serum was recorded before surgery and after the development of recurrence.