Open AccessGANGLIONEUROBLASTOMA CONTAINING SEVERAL KINDS OF NEURONAL PEPTIDES WITH WATERY DIARRHEA SYNDROME
Author(s) -
Yagihashi Soroku,
Shimoyama Norihiko,
Morita Takayuki,
Sato Tatsusuke,
Yanaihara Noboru
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb03195.x
Subject(s) - vasoactive intestinal peptide , immunoperoxidase , ganglioneuroblastoma , pathology , achlorhydria , staining , enteroendocrine cell , autopsy , secretory vesicle , neural crest , chemistry , biology , medicine , endocrinology , hormone , antibody , microbiology and biotechnology , immunology , secretion , exocytosis , cell culture , neuropeptide , endocrine system , ganglioneuroma , receptor , monoclonal antibody , genetics , neuroblastoma , stomach , embryo
This report presents an adrenal ganglioneuroblastoma containing several kinds of neuronal peptides. The tumour was found in an autopsy case of a 3‐year‐old girl with clinical manifestation of intractable diarrhea, hypokalemia, achlorhydria, and with elevated levels of plasma vasoactive intestinal peptide (VIP). Immunoperoxidase staining showed many immuno‐reactive VIP‐ containing cells, some somatostatin‐and substance P‐contalning cells on the tumour sections. Ultrastructurally, the tumour cells contained numerous secretory granules that could be divided mainly into two types; one is a small cored vesicle (50‐150 nm in diameter) and the other large electron dense secretory granule (200‐500 nm in diameter). It was suggested that the cells in ganglioneuroblastoma derived from neural crest are closely related to the cells that could differentiate into gut‐hormone‐producing cells.