Open AccessMEDULLARY CARCINOMA OF THE THYROID WITH ECTOPIC ACTH SYNDROME
Author(s) -
Kakudo Kenichi,
Miyauchi Akira,
Ogihara Toshio,
Takai Shinichiro,
Kitamura Hajime,
Kumahara Yuichi,
Kawaoi Akira
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb03193.x
Subject(s) - calcitonin , medullary carcinoma , pathology , thyroid , medicine , medullary cavity , immunohistochemistry , somatostatin , endocrinology , thyroid carcinoma
An autopsied patient with medullary carcinoma of the thyroid and ectopic ACTH syndrome is reported. A microadenoma of pancreatic islet coexisted in this case, which is assumed to be of D cell origin. Immunohistochemical study revealed decreased number of pituitary ACTH cells. Some of them showed Crooke's degeneration. Hormone assay study of tumor tissue and plasma disclosed abnormal ACTH, β‐MSH as well as calcitonin. Somatostatin and Substance P were also demonstrated in tissue. Histologically the tumor showed solid alveolar pattern with a minor part consisting of small cell variant and this histologic variation is discussed.