Open AccessULTRASTRUCTURE AND IMMUNOHISTOCHEMISTRY OF GASTRO‐ENTERO‐PANCREATIC (GEP) ENDOCRINE CELLS IN MUCINOUS TUMORS OF THE OVARY
Author(s) -
Takeda Akihiro,
Matsuyama Mutsushi,
Chihara Tsutomu,
Suchi Taizan,
Sato Tsuneko,
Tomoda Yutaka
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb02080.x
Subject(s) - enteroendocrine cell , pathology , gastrin , endocrine system , immunoperoxidase , somatostatin , adenocarcinoma , biology , mucinous carcinoma , pancreas , medicine , endocrinology , cancer , secretion , hormone , antibody , immunology , monoclonal antibody
Twenty three mucinous tumors were studied by histochemical, auto‐fluorescence and immunoperoxidase methods, and electron microscopy to investigate the existence of gastro‐entero‐pancreatic (GEP) endocrine cells in mucinous tumors of the ovary. Out of 11 mucinous adenomas, 6 cases contained autofluorescence positive (EC‐) cells and 1 case contained somatostatin‐and gastrin‐cells. Out of 4 borderline malignancies, 4 cases contained EC‐cells and 3 cases contained somatostatin‐ and gastrin‐cells, and of 8 mucinous adenocarcinomas, 3 cases contained somatostatin‐cells and 2 cases contained EC‐ and gastrin‐cells. Electron microscopic observations of 7 cases including 4 mucinous adenomas, 2 borderline malignancies, and 1 adenocarcinoma revealed 3 different types of endocrine‐type granulated cells including EC‐, D‐and G‐cells. Furthermore, muco‐endocrine cell was found in a mucinous adenoma case. These findings agree with the results from autofluorescence and immunoperoxidase studies. The histogenetic origin of mucinous tumors is rather problematic and the appearance of various types of GEP endocrine cells support their endodermal derivation. These results strongly support the possibility that GEP endocrine cells in mucinous tumors are developed in loco from precursor endodermal cells.