Open AccessIMMUNOHISTOCHEMICAL OBSERVATION OF INTRACYTOPLASMIC LYSOZYME IN PROLIFERATIVE AND NEOPLASTIC FIBROHISTIOCYTIC LESIONS
Author(s) -
Nakanishi Sumio,
Shinomiya Sadao,
Sano Toshiaki,
Hizawa Kazuo
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb02077.x
Subject(s) - dermatofibrosarcoma protuberans , lysozyme , histiocyte , pathology , immunoperoxidase , immunohistochemistry , dermatofibroma , biology , medicine , immunology , antibody , genetics , monoclonal antibody
Distribution of intracytoplasmic lysozyme in proliferative and neoplastic fibrohistiocytic lesions and non fibrohistiocytic tumors was studied by immunoperoxidase technique on formalin fixed, paraffin‐embedded sections. The cases examined were 161 fibrohistiocytic lesions and 86 non‐fibrohistiocytic tumors. Contrary to our expectation, the lysozyme positive cells were found only in the minority of cases with fibrohistiocytic lesions. Cells positive for lysozyme were found only in 13 out of 100 cases of dermatofibroma, one out of 4 cases of xanthogranuloma and 8 out of 33 cases of malignant fibrous histiocytoma. Dermatoflbrosarcoma protuberans and non‐fibrohistiocytlc tumors were negative for lysozyme. It is suggested that In proliferative fibrohistiocytic lesions, Induction of lysozyme synthesis is weak or absent. Some malignant fibrous histiocytomassh owed scattered lysozyme positive neoplastic cells, indicating their probable histiocytic origin or differentiation. On the other hand, evidence of histiocytic differentiaton of dermatofibrosarcoma protuberans was not obtained using lysozyme immunohistiochemistry.