Open AccessADENOMA WITH MULTIPLE HYPERPLASTIC NODULES IN NONCIRRHOTIC LIVER POSSIBLY RELATED TO LONG‐TERM ADMINISTRATION OF A HYPOLIPIDEMIC DRUG
Author(s) -
Mori Hideki,
Tanaka Takuji,
Sugie Shigeyuki,
Takahashi Masayoshi
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb02068.x
Subject(s) - medicine , pathology , adenoma , term (time) , drug , drug administration , administration (probate law) , hyperplasia , hepatocellular adenoma , gastroenterology , pharmacology , political science , physics , quantum mechanics , law
Described here is an autopsy case of a 76‐year‐old woman with preneoplastic and other adenomatous hepatocellular lesions. Multiple small hyperplastic liver foci with PAS positive reaction and adenomatous nodular lesions were noted in a non‐cirrhotic liver. These lesions resembled altered foci or neoplastic nodules which are currently regarded as premalignant changes in experimental animal models. It is suggested that the liver lesions of this woman may be related to long‐term administration of hypolipidemic drug cloflbrate for hypercholesteremia and the lesions could be one of the precursor changes of human hepatocellular carcinoma.