Open AccessDERMATOFIBROSARCOMA PROTUBERANS AND ITS TISSUE CULTURE STUDY
Author(s) -
Yoshida Haruhiko,
Matsui Katsuaki,
Hashimoto Kimio,
Yumoto Tokichi,
Mihara Motoyuki
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb02029.x
Subject(s) - dermatofibrosarcoma protuberans , histiocyte , pathology , biology , endoplasmic reticulum , immunohistochemistry , electron microscope , microbiology and biotechnology , medicine , physics , optics
Dermatofibrosarcoma protuberans arizing in the thigh of a 23‐year‐old female is reported with an investigation of tumor cell character by electron microscopy, enzyme histochemistry, immunological and in vitro tissue culture techniques. The tumor tissue showed histologically a peculiar storiform arrangement of plump spindle cells with dense proliferation. Electron microscope revealed histiocytic cell structures of some tumor cells; lysosomes, phagosomes, and sparse rough endoplasmic reticula. They revealed diffuse positive reactions to acid phosphatase (Ac Pase) and nonspecific esterase. Short‐time culture of the tumor tissue indicated rather round and polygonal cells admixed with spindle cells, positive to Ac Pase and non‐specific esterase with diffuse reaction. Most of the round cells possessed Fc and C3 receptors on their surface and phagocytic activity. Dermatoflbrosarcoma protuberans is probably a histiocytic tumor and structural characteristics of Schwann cells were not recognized.