Open AccessSYSTEMIC LUPUS ERYTHEMATOSUS ASSOCIATED WITH MULTIPLE NODULAR HYPERPLASIA OF THE LIVER
Author(s) -
Kuramochi Shigeru,
Tashiro Yukio,
Torikata Chikao,
Watanabe Yonosuke
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb01410.x
Subject(s) - medicine , nodular regenerative hyperplasia , pathology , portal hypertension , nodule (geology) , cirrhosis , hyperplasia , lupus erythematosus , autopsy , pulmonary hypertension , sclerodactyly , gastroenterology , calcinosis , calcification , immunology , paleontology , antibody , biology
Three autospy cases of systemic lupus erythematosus with uinique association of multiple nodular hyperplasia (MNH) of the liver, portal hypertension, and hypertensive pulmonary vascular disease are reported. None of the patients had received oral contraceptive or androgenic steroid, but they were treated with glucocorticoids for 2 to 11 years. Raynaud's phenomenon, sclerodactyly, and mild impairment of the kidney were the common clinical features. Macroscopically, MNH is characterized by many nodules scattered throughout the non‐cirrhotic liver, and histologically, each nodule is made up of normal‐appearing hepatocytes and not encapsulated. Portal tracts are scanty in the nodules. MNH seems to be a regenerative‐hyperplastic process, but its true nature still remains unclear. Relationships between MNH and portal hypertension, MNH and pulmonary hypertension, and collagen disease and pulmonary hypertension are discussed. A brief review of the literature concerning multiple benign hepatocellular tumors similar to MNH is also presented. ACTA PATHOL. JPN. 32: 547∼560, 1982.