Open AccessCELLS CONSTITUTING CEREBELLAR HEMANGIOBLASTOMAS Ultrastructural Study
Author(s) -
Seyama Shinichi,
Ohta Michiya,
Nishio Shunji,
Matsushima Toshio,
Kitamura Katsutoshi
Publication year - 1982
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1982.tb01397.x
Subject(s) - pathology , stromal cell , hemangioblastoma , cell type , ultrastructure , biology , anatomy , cell , medicine , genetics
Five capillary hemangioblastomas exhibiting a range of histologic variations common to this tumor were studied using electron microscopy. The capillary hemangioblastomas were composed commonly of three cell lines — stromal cells, endothelial cells and pericytes. In addition, extramedullary hematopoietic foci were seen in the tumor tissue of one case. We regarded all these cellular elements as neoplastic components. The interconvertibility among them was not confirmed. The capillary hemangioblastomas were highly organized by those multiple cell lines. The histologic pattern of growth was arbitrarily subgrouped into stromal cell prominent type and capillary prominent type. Intermediate features between the two types were observed. These different types would depend on relative proportions and the degree of maturity of the constituting cell elements. From the histogenetic point of view, we considered capillary hemangioblastomas as being a hamartomatous tumor.