Open AccessHISTOPATHOLOGICAL IDENTIFICATION OF HEPATIC INTRAMITOCHONDRIAL CRYSTALLOID INCLUSIONS (IMCI)
Author(s) -
Tange Tsuyoshi
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb02800.x
Subject(s) - pathology , h&e stain , parenchyma , staining , beagle , necrosis , medicine , biology
A 45‐year‐old female with systemic lupus erythematosus underwent liver biopsies twice during the period of cefazolin administration and a complication of cefazolin‐induced toxic hepatitis was strongly suggested. Histologically, a small number of spindle‐shaped, esoinophilic crystalloid bodies were faintly noticed in the cytoplasm of hepatocytes in hematoxylin and eosin‐stained sections, while they showed strong positivity for stains inherent to mitochondria as well as specific to phospholipid and sharply showed a spindle or needle shaped configuration. Moreover, they greatly increased in number in these sections. They were distributed throughout the parenchyma but were prominent in the degenerated hepatocytes with slight fatty metamorphosis. Electron microscopically, they proved to correspond to the intramitochondrial crystalloid inclusions (IMCI). Despite many ultrastructural descriptions of the IMCI, precise histopathological examination of the IMCI referring to the staining property on the deparaffinated sections has not yet been described since the first report of the IMCI by N apolitano (1958). 14