Open AccessRECEPTORS FOR HELIX POMATIA AGGLUTININ ON NORMAL AND NEOPLASTIC LYMPHOCYTES
Author(s) -
Tsutsumi Yutaka
Publication year - 1981
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1981.tb02760.x
Subject(s) - helix pomatia , pathology , agglutinin , biology , medicine , anatomy , immunology , lectin , snail , ecology
In order to investigate the distribution and significance of receptors for Helix pomatia agglutinin (HPA), paraffin sections from several reactive and 71 neoplastic lymphoid tissues were utilized for a histochemical study after neuraminidase treatment. Lymphocytes in the germinal center and thymic cortex were mostly negative for the receptors, while most of the lymphocytes in the thymus‐dependent area, some of those in the primary follicle or in the marginal zone and most of the plasma cells in the medulla possessed the receptors on their surfaces. Nodular lymphomas, thymomas and diffuse lymphoblastic lymphomas were mostly negative in contrast to the positive reaction in diffuse poorly differentiated lymphomas of B‐cell type and plasmocytomas. Diffuse histiocytic lymphomas and diffuse mixed lymphocytic and histiocytic lymphomas occasionally possessed the receptors, irrespective of their immunological markers. Hodgkin's cells were negative on their surfaces, but were occasionally positive in their cytoplasms as seen in case of histiocytes. From these results, HPA receptors could be neither T‐cell nor B‐cell differentiation marker. The possibility that HPA‐receptor‐negative lymphocytes may have a quick turn‐over rate or a short life span is also discussed.